The development of a new medicine starts when basic scientists learn of a biological target (e.g., a receptor, enzyme, protein, gene, etc.) that is involved in a biological process thought to be dysfunctional in patients with a disease such as Alzheimer's disease (AD). Here, we are considering the discovery and development of entirely new medicines, those with a mode of action different from already approved medicines and intended for a clinical indication that is not addressed by approved medicines. Better medicines that are iterative improvements on current medications are valuable as they may offer benefits over existing medications in terms of potency, safety, tolerability, or convenience, but they usually don't involve the manipulation of biological targets different from those directly suffering from existing medications. Analyses across all therapeutic areas indicate that the event of a replacement medicine, from target identification through approval for marketing, takes over 12 years and sometimes much longer. At the same time, they are often very skeptical of new findings in the scientific literature that claim to have identified a NBE or process that could be a target of interest. The investment in time and money needed to pursue a replacement biological target is extremely large in order that drug developers nearly always plan to reproduce reported findings before engaging in screening against novel targets; such efforts to reproduce even findings reported in the most reputable journals find that most, maybe even as many as 90%, cannot be reproduced.
Scientific Tracks Abstracts: Epilepsy Journal
Scientific Tracks Abstracts: Epilepsy Journal
Keynote: Epilepsy Journal
Keynote: Epilepsy Journal
Posters & Accepted Abstracts: Neurological Disorders
Posters & Accepted Abstracts: Neurological Disorders
Keynote: Neurological Disorders
Keynote: Neurological Disorders
Posters-Accepted Abstracts: Neurological Disorders
Posters-Accepted Abstracts: Neurological Disorders
Abnormal and Behavioural Psychology received 361 citations as per Google Scholar report
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