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Clinical and Medical Case Reports

Clinical and Medical Case Reports

ISSN: 2684-4915

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Clinical Medical Informatics Journals

The quality of T cell responses differs dramatically during infancy and has been implicated within the susceptibility to infections, but the underlying cellular pathways aren't documented. Here, we set on the effector phenotype of T cells in adenoids of 103 children with adenoid hypertrophy that underwent adenoidectomy. We compared children with sole upper airway obstruction with those affected by concomitant otitis with effusion or recurrent infections of the upper airways. The multifunctionality of T cells was determined as co-production of IFNg, IL2, IL17, and TNFa using flow cytometry. Boolean gating was accomplished in FlowJo and analyzed using SPICE software. Statistical analysis was done by one-way-ANOVA. We found that CD4 and CD8 T cells of all disease groups and at any examined age were ready to co-produce all possible cytokine combinations. For CD8 T cells, patients exclusively showing upper airway obstruction accumulated 28% more triple and 30% more double producers compared with those suffering from subsequent infectious symptoms, while the latter had 15% more single producers. CD4 T cells showed similar results.

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Citations: 53

Clinical and Medical Case Reports received 53 citations as per Google Scholar report

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