Ischemic heart disease remains the leading cause of death and morbidity in diabetic patients. Post-conditioning of ischemia has been shown to be an effective way to control ischemia-myocardial reperfusion injury, but the cardioprotective effects of IpostC are compromised or diminished in patients with diabetes, a metabolic disease associated with reduced levels of adiponectin. The objectives of the present study were to determine the role of AFN in the cardioprotective effect mediated by IPostC and to study the underlying molecular mechanisms. Wild type and APN knockout mice were subjected to a 30 min coronary artery ligation followed by 2 hours of reperfusion, in the absence or presence of IPostC, performed by 3 episodes 10 s reperfusion and 10 s reocclusion immediately after ischemia. Myocardial functions were assessed by the volume pressure (PV) conductance system. The size of post-ischemic myocardial infarction was larger in AKO than in WT, which was associated with a significant reduction in myocardial p-eNOS expression and the final systolic PV relationship, a measure reliable ventricular systolic function in AKO. On the other hand, IPostC considerably reduces the size of the infarction and improves the final systolic PV relation, as well as a significant increase in the expression of myocardial APN, in WT but not in AKO. It is concluded that improving myocardial APN may represent a key mechanism by which IPostC confers cardioprotection. Zhengyuan Xia, ischemia post-conditioning alleviates myocardial ischemia reperfusion injury by upregulating the expression of cardiac adiponectin in mice.
Keynote: Cancer Science & Therapy
Keynote: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Journal of Nephrology & Therapeutics
Scientific Tracks Abstracts: Journal of Nephrology & Therapeutics
Journal of Coronary Heart Diseases received 15 citations as per Google Scholar report
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