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Journal of Physiotherapy & Physical Rehabilitation

Journal of Physiotherapy & Physical Rehabilitation

ISSN: 2573-0312

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Any chronic inflammatory disease can put you at increased risk for osteoporosis, says Edwards, because it appears to increase the rate of bone turnover, in which the old bone is replaced with new, healthy bone. People with lupus and rheumatoid arthritis usually take corticosteroids for an extended period of time to manage their symptoms. Long-term use of steroids such as prednisone is also a major cause of osteoporosis, possibly because they slow down the activity of bone building cells.

 

Lupus is a particular problem, as it is common in women aged 15 to 45, often during the peak years of bone building up to 30 years of age. Diabetes increased the intensity and duration of the inflammatory infiltrate (P <0.05). The formation of the osteoclasts and the percentage of bone eroded after 7 days of placing the ligature was similar, while four days after the elimination of the ligations, the type 2 diabetic group had a significant number and activity of the osteoclasts. higher (P <0.05). The amount of new bone formation after resorption was 2.4 to 2.9 times higher in normoglycemic rats than in diabetic rats (P <0.05). Diabetes also increased apoptosis and decreased the number of bone mucosal cells, osteoblasts and periodontal ligament fibroblasts (P <0.05). Thus, diabetes caused a more persistent inflammatory response, greater loss of attachment and greater alveolar bone resorption, and impaired the formation of new bones. The latter may be affected by increased apoptosis of the cells of the bone mucosa and of the PDL cells.

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Citations: 378

Journal of Physiotherapy & Physical Rehabilitation received 378 citations as per Google Scholar report

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