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Medical Microbiology & Diagnosis

Medical Microbiology & Diagnosis

ISSN: 2161-0703

Open Access

Anti-HBc Top Open Access Journals

Hepatitis B is a serious global infectious disease and a leading cause of death and morbidity worldwide. However, data on occult hepatitis B in Iran are sparse. The present study evaluated the frequency of anti-HBc and HBV DNA in a serum sample of healthy blood donors negative for HBsAg stratified by sex and age; and also studied the relationship between detection of HBV DNA and anti-HBc positivity. Since screening for anti-HBc is not done in the Iranian blood bank, we assessed whether anti-HBc could be adopted as a test for donated blood. The study included a total of 1,525 blood samples from hepatitis B virus surface antigen negative for the hepatitis B virus (87% of men with mean age ± SE: 31 ± 8 years; and 13% of women with an average age ± SD of 30 ± 6 years). Eight percent (121 of 1525) of the HBs-Ag negative blood samples were positive for Anti-HBc and were all male. HBV DNA was detected in 36 of 121 anti-HBc + samples (29.7%). The study found a positive relationship between anti-HBc positivity and detection of HBV-DNA in serum samples from HBs-Ag negative blood donors. The results of this study suggest that the introduction of anti-HBc screening in Iran may be very practical in order to limit the risk of transmission of the occult hepatitis B virus by blood transfusion.

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Citations: 14

Medical Microbiology & Diagnosis received 14 citations as per Google Scholar report

Medical Microbiology & Diagnosis peer review process verified at publons

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