Moomin Hussain Bhat*, Shivani Sidana and Shariq Rashid Masoodi
Beckwith Wiedemann syndrome is rare congenital overgrowth syndrome. This syndrome usually presents in neonates with macroglossia, large birth weight, omphalocele, visceromegaly and hypoglycemia. However, there is little information available regarding the natural history in adults with BWS. Here we present a case of Beckwith-Wiedemann syndrome with its major manifestations but without hypoglycemia that was misdiagnosed in infancy with mucopolysaccharidosis and presented to us at 14 years of age with tall stature.
Rooth Vasantha Medapati*, Raja Sai Sathvik Godi, Meghana Dasari, Aparanji Poosarla, Sridevi Suvvari, Saritha Medapati and Sudhakar Godi
DOI: 10.37421/2684-4567.2023.7.42
Introduction: Coronavirus has caused a major burden to mankind since the end of the year 2019 and is still persisting. School going children play a vital role in sustaining the human race and it is necessary to educate them about Coronavirus disease and inculcate in them the preventive measures to minimize its outbreak. This study is aimed to determine the level of awareness and knowledge on preventive measures of this disease and to find their association with demographic variables in high school students.
Methods: A close ended questionnaire based demographic study was done to assess the awareness and knowledge of COVID-19 on 242 school children, Visakhapatnam, Andhra Pradesh, India. The collected data was statistically analyzed.
Results: The study revealed that the highest percentages of students were in the age group of 14 years (41.73%) and majority of them were female (52.89%). Most of the students were residing in urban area (67.35%). The maximum source of knowledge about the disease was from mass media (75.61%). Awareness associated studies showed significance with the variables of age group (P=0.004), area of residence (P=0.04), and nutritional status of the students (P=0.016), while the knowledge related studies showed significance with only nutritional status of the students (P=0.001). Students residing in rural area decreased the odds of awareness. Female students and 13 years of age students having marginal nutrition have increased the odds of having awareness. Students who are having good health increased the odds of knowledge while those who were over nutrition decreased the odds of knowledge on preventive measures. (P<0.05 was considered as significant).
Conclusion: The study denotes that the efforts of the global health authorities in imparting the necessary steps through mass media to save the public were successful. More awareness and knowledge through mass media increases the tendency of gaining knowledge and awareness towards COVID-19. It is suggestible to include modern technologies and also breathing exercises in school curriculums to protect the students from COVID-19. Further study on various aspects of this respiratory disease with larger sample size will help in acquiring an indepth knowledge on corona virus.
DOI: 10.37421/2684-4567.2023.7.43
DOI: 10.37421/2684-4567.2023.7.94
DOI: 10.37421/2684-4567.2023.7.87
The unassuming yeast species, Saccharomyces cerevisiae, frequently takes center stage in the fields of microbiology and synthetic biology. Known for its integral role in baking and brewing, this versatile microorganism has been gaining increasing recognition for its remarkable capabilities in genetic engineering. Recent breakthroughs have elevated S. cerevisiae to become a resilient and effective host for replicating microbial genomes, unlocking fresh possibilities for manipulating bacteria and viruses. In this article, we venture into the intriguing domain of S. cerevisiae as a host for microbial genomes and investigate the recent advancements that have facilitated streamlined genome engineering and the introduction or modification of microbial genomes through transplantation or transfection.
DOI: 10.37421/2684-4567.2023.7.88
Inborn Errors of Metabolism (IEMs) constitute a set of rare genetic disorders that disrupt the body's normal chemical processes. Though these conditions have traditionally been linked to pediatric patients, there is a mounting body of evidence indicating that they are significantly underdiagnosed in the adult population. This article delves into the issue of underdiagnosis, focusing on a notable revelation: in one adult genetics clinic, biochemical testing resulted in a diagnostic rate of merely 10%. This finding underscores the pressing need for heightened awareness, improved diagnostic techniques and a deeper understanding of IEMs in adults. Historically, inborn errors of metabolism have primarily been associated with childhood due to the emergence of severe symptoms at a young age. However, both research and clinical experiences are increasingly suggesting that numerous adults may unknowingly be living with undiagnosed IEMs. These disorders can exhibit a wide spectrum of symptoms, rendering their identification in the adult population a challenging task. Moreover, these symptoms frequently overlap with more common conditions, further complicating the diagnostic process.
DOI: 10.37421/2684-4567.2023.7.89
DOI: 10.37421/2684-4567.2023.7.91
DOI: 10.37421/2684-4567.2023.7.92
DOI: 10.37421/2684-4567.2023.7.93
DOI: 10.37421/2684-4567.2023.7.95
In the intersection of neuroscience and genetics, collaboration has emerged as a formidable driving force for making significant discoveries. Global collaborations focused on neuroimaging genetics have proven to be a potent means of advancing our comprehension of the human brain. These endeavors bring together researchers from various corners of the globe, facilitating the aggregation and comparative analysis of brain data and the replication of research findings. The promise of groundbreaking insights is substantial, but so too are the ethical complexities inherent in such worldwide collaborations. This article delves into the potential hurdles and advantages associated with these collaborative efforts, underscoring the importance of deliberate ethical deliberations in this rapidly progressing field.
Bin Zhao*
The duplicate of a short coded DNA code that is not coded is known as Satellite DNA. This repetition of the orphans is presented next to each other. Cone repetitions can be of one type or more than one type. Satellite DNA is involved in the unencrypted fragment of DNA strands that can encode any protein. The satellite got its name because of the detection of DNA at a human gradient that was found to be in the centrosomic component of chromosomes, therefore, centromere and heterochromatin are said to be a rich source of these mutations. Due to the nature of coding it was initially thought to be unhealthy DNA; however it has been suggested by some that they will contribute to the functioning of chromosomes. Basic satellite pairs range from 1bp to a few base pairs. Aploid human DNA was found to have 170 basic pairs, while beta-satellite DNA is
found in the chromosomes of 1, 9, 13, and 14,15,21,22 chromosomes and in the Y chromosome and 68 base cells as a complete set of chromosomes. Many copies of nucleic
acids are available in a sequence of sequences involving DNA or RNA. The repetition of this sequence can be divided into the following three categories: Terminal Repetition, Terminal Repetition and Focused Repetition. Repetition of tandem is made up of arrangements close to repeated nucleic acids that may be of one type or more than one type. These duplicates of tandem include satellite DNA, microsatellite and minisatellite. Satellite DNA is a duplicate of coding. Microsatellite is a small repetition of the range ranging from a distance from 1-6 or more to two basic.
Jun Inoue*
Germs have both living and non-living characteristics. A unique feature that distinguishes germs from other organisms is the fact that they need other substances in order to survive. Therefore, they are considered responsible parasites. Bacteria can spread in many ways which are Airborne - Bacteria infect their carriers in the open air, Blood Borne - Transmission between organisms when infected blood enters the circulatory system, Pollution - It is caused by the use of substances such as water and contaminated food
inside. Thus, viruses have many ways of transmitting from one creature to another. Small germs, because of their size and simplicity, they cannot replicate themselves independently. Therefore, when a virus is detected in a host, it needs recycling methods before it can be eliminated without producing other viruses. This is done by altering the cell's genetic makeup to begin encoding the material needed to make more viruses. By modifying the cell commands, more viruses can be produced.
Liu Li-feng, Yang Xin-Lei, Liu Kaige, He Mei-Jing, Cui Shun-Li, Mu Guo-Jun, Wang Liang, Li Li, Yan Congcong, Zhao Nannan, Chen Yingjie and Addisu Getahun*
The present study was conducted to predict genotypic variability, phenotypic variability, heritability, and genetic advance on pod and seed-related traits in cultivated peanut RIL population. Genetic variability is an important prerequisite for selection using certain genetic parameters viz: genotypic variation, heritability and genetic advance.
The trait pod length, number of pods per plant, pod weight per plant, multi-seedpods per plant had high genotypic coefficient of variation. The highest narrow sense heritability was recorded in seed length, pod length by width, and pod thickness traits, meanwhile, seed length, seed length by width, number of pods per plant, shelling percentage, pod thickness, thickness of pod shells, seed weight per plant, seed thickness, seed width, multiple seedpods per plant, and pod weight per plant traits had high broad sense heritability. The highest genetic advance as percent of mean had occurred in multiple seedpods per plant, number of pods per plant, pod weight per plant, seed weight per plant, thickness of pod shells, pod length by width, seed length by width, and seed length quantitative traits. The highest broad sense heritability values coupled with high genetic gain were estimated in multiple seedpods per plant, number of pods per plant, pod weight plant, seed weight per plant, thickness of pod shells, pod length by width, seed length by width. Therefore, relatively the present study used more pod and seed-related traits than the previous investigations. The present experiment had tried to estimate a good quantitative trait inheritance and genetic variability between recombinant inbred line populations; so far, our result suggested that superior breeding line selection was confidential for next breeding programs.
Journal of Genetics and Genomes received 56 citations as per Google Scholar report
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