Journal of Lung Diseases & Treatment

ISSN: 2472-1018

Open Access

Teresinha Leal

Teresinha Leal

Teresinha Leal
Louvain Centre for Toxicology and Applied Pharmacology (LTAP) Institute of Experimental and Clinical Research (IREC) Université catholique de Louvain Brussels, Belgium


Half-time Clinical and Basic Researcher, IREC/UCL, Brussels-Belgium
Half-time Clinical and Basic Researcher, FRSM, Brussels-Belgium
Permanent Part-time Associate Professor, Université catholique de Louvain, Brussels-Belgium

Research Interest

My major research interest in the clinical field is to contribute to the biochemical diagnosis of the autosomal genetic disease Cystic Fibrosis (CF). I am in charge of the supervision of the sweat test at St Luc University Hospital (~300 tests/year). Have been involved in the development and standardization of the nasal potential difference test for which I have acquired a great internationally recognized expertise.

• In the experimental field, I have developed (since 2004) a research unit in my department. Several projects are studied using a CF mouse model colony homozygous for the most common CF mutation, the F508del mutation. Briefly, the main projects consist on investigating: the underlying mechanisms of lung inflammation in CF and its modulation by azithromycin and other anti-inflammatory drugs; the pathophysiological mechanisms of CF regarding the respiratory and the gastrointestinal tract; the role of small drug molecules (selective phosphodiesterase type 5 inhibitors, resveratrol, ….) as activators of the mutant CFTR protein in CF and potential therapies for CF disease.

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