Leandro Bueno Bergantin
Department of Pharmacology
Federal University of São Paulo, SÃ£o Paulo, Brazil
Dr. Bergantin received his academic education at EPM-UNIFESP (Brazil) and UAM (Spain): biomedicine (2008), MSc (2010) and PhD (2014). His research involves cell signaling mediated by Ca2+ and cAMP, including its role in neuropsychopharmacology, autonomic and cardiovascular pharmacology, and cancer. His research work solved the enigma of the paradoxical effects produced by L-type Ca2+ channel blockers (ScienceDirect TOP 25 Hottest Articles - Biochemistry, Genetics and Molecular Biology - Cell Calcium). Since 1975, several clinical and experimental studies have reported that acute and chronic administration of L-type Ca2+ channel blockers (CCB), such as nifedipine, produces reduction in arterial pressure associated with a paradoxical increase of sympathetic activity. In 2013, Dr. Bergantin and collaborators discovered that this paradoxical increase in sympathetic activity produced by L-type CCB is due to interaction of the Ca2+/cAMP signaling pathways. Then, the pharmacological manipulation of this interaction could be a new therapeutic strategy for increasing neurotransmission in psychiatric disorders, and producing neuroprotection in the neurodegenerative diseases (Bergantin and Caricati- Neto, 2016 Eur J Pharmacol; Caricati-Neto et al., 2015 Pharm Res Perspect). In addition, the pharmacological handling of the Ca2+/cAMP signaling interaction could be a more efficient therapeutic approach to inhibit cancer tumor progression (Errante PR et al., 2017 Adv Cancer Prev; Errante PR et al., 2017 J Clin Exp Oncol). Dr. Bergantin has published several articles in international journals (>50 articles, H-index: 9, citations: 219, source: google scholar - 11/09/2017), book chapters and an international book. He is member of several editorial boards of international journals (>80, including editor-in-chief of 3 international journals). Dr. Bergantin has been frequently invited (every week) to be honorable guest (speaker) in international conferences, and to participating in media interviews.
Neurology, Biochemistry, Genetics and Molecular Biology