Joel S Greenberger
Professor and Chairman, Dept. of Radiation Oncology
University of Pittsburgh Medical Center, Pittsburgh, PA., United States
Dr. Greenberger is currently Principal Investigator on the Center for Medical Countermeasures Against Radiation (CMCR) Grant from the NIAID. He also is Principal Investigator on Project 1 “MnSOD-PL Intravenous Administration for Prevention of Total Body Irradiation-Induced Toxicity,” and the Principal Investigator on the Pilot Projects Core, and the Education and Development Core of the CMCR Grant.
Methods by which to decrease bone marrow stromal cell migration into the lungs have included demonstration that the SMAD3-/- bone marrow chimeric mice show decreased fibroblast migration in the lungs, due to their inability to respond to TGFβ, the cytotoxic cytokine and fibrosis inducing cytokines produced by irradiated lung. We have also demonstrated the bone marrow origin of fibroblast progenitor cells for the fibrotic lesions in pulmonary fibrosis. Research is currently underway to determine the initial molecular events in irradiated lung which lead to TGFβ production and initiation of migration of bone marrow cells forming fibrosis.