Department of Rehabilitation Medicine, The second affiliated hospital of Xinjiang medical University, China
Research
Skilled Aerobic Exercise Reduces Endoplasmic Reticulum Stress and Dopamine Neuron Apoptosis by Activating Wnt/β-Catenin Pathway and Improves Motor Function in Pd Model Rats
Author(s): Tian Ruisi, Zhu Zhengquan, Gao Hua, Li Peishan, Yang Xinling Li and Lin Yan-xia*
Objective: To observe whether skilled aerobic exercise (SAE) could reduce endoplasmic reticulum stress (ERS) and apoptosis of dopamine neuron by activating Wnt/β-catenin pathway and improves motor function in Parkinson' s disease (PD) model rats.
Methods: The PD models were established by injection into the right SNC (substantia nigra, compact part) and VTA (ventral tegmental area) on the rat stereolocator with 6-hydroxydopamine (6-OHDA). A cylindrical test was used to was used to test motor function. The expression of tyrosine hydroxylase (TH) in midbrain was detected by immunohistochemistry, the expression of genes and proteins related to the Wnt/β-catenin pathway was detected by Western blot. The level of Irisin in serum was identified through an enzyme-linke d immunosorbent assay (ELISA).
Results: .. Read More»
DOI:
10.4172/2329-6895.10.8.507
Neurological Disorders received 937 citations as per Google Scholar report
