Journal of Hypertension: Open Access

Department of Physiology, Jagiellonian University Medical College, 30-663 Krakow, Poland

Publications

• Mini Review   
  Cannabinoid Receptor Activation Mitigates Hypertension via Glycolysis Inhibition in Microglia
  Author(s): Velez Kapadia*
  
  Hypertension, characterized by elevated blood pressure, is a major risk factor for cardiovascular diseases and is often associated with neuroinflammation, contributing to the progression of vascular dysfunction. Recent studies have elucidated the therapeutic potential of cannabinoid receptor activation in mitigating hypertension-related neuroinflammation. Specifically, activation of the Cannabinoid Type 2 Receptor (CB2R) in microglia, the resident immune cells of the central nervous system, has emerged as a promising strategy for alleviating neuroinflammatory responses. This review highlights the molecular mechanisms underlying the anti-inflammatory effects of CB2R activation in microglia, focusing on the inhibition of aerobic glycolysis, a metabolic pathway implicated in the pathogenesis of neuroinflammation. By targeting key enzymes and transporters involved .. Read More»
  DOI: 10.37421/2167-1095.2024.13.443

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