Department of Medical Laboratory Science, Igbinedion University Teaching Hospital, Okada, Edo State, Nigeria
Research Article
Antioxidant Trace Elements Depletion Induces Proinflammatory Cytokines Polarization in Anti Diabetics Drug Naive Non Obese Male Type 2 Diabetic Nigerians
Author(s): Ehiaghe Friday Alfred*, Udiyiwe Osaikhuwuomwan, Uwaifo Nicholas Eghosa, Ehiaghe Imuetinyan Joy, Eremwanarue Aibuedefe Osagie, Usiosefe Raphael Erhunmwunse and Digban Awharentomah Kester
Type 2 diabetes (T2D) is a major risk factor for cardiovascular diseases and acute oxidative stress (OS) by high production of reactive oxygen
species (ROS) related to the lipotoxicity and glucotoxicity processes. The study was aimed at evaluating the cytokine responses and antioxidant
trace elements status using the blood levels of interleukin-1 alpha, interleukin-4, zinc nickel, magnesium, and chromium circulating among antidiabetics
drug naïve non-obese male type 2 Diabetic Nigerians. A total of 124 subjects (aged between 20 and 40 year) were randomly studied,
among these were 64 known cases of type 2 diabetes mellitus with a poor glycemic control index and 60 apparently healthy individuals with a good
glycemic index. Student’s t- test was used to compare independent variables. Cytokine levels were determined by enzyme-linked immunosorbent
assay m.. Read More»
DOI:
10.37421/1948-593X.2022.15.364
Journal of Bioanalysis & Biomedicine received 2511 citations as per Google Scholar report
