Journal of Bioanalysis & Biomedicine

Department of Medical Laboratory Science, Igbinedion University Teaching Hospital, Okada, Edo State, Nigeria

Publications

• Research Article   
  Antioxidant Trace Elements Depletion Induces Proinflammatory Cytokines Polarization in Anti Diabetics Drug Naive Non Obese Male Type 2 Diabetic Nigerians
  Author(s): Ehiaghe Friday Alfred*, Udiyiwe Osaikhuwuomwan, Uwaifo Nicholas Eghosa, Ehiaghe Imuetinyan Joy, Eremwanarue Aibuedefe Osagie, Usiosefe Raphael Erhunmwunse and Digban Awharentomah Kester
  
  Type 2 diabetes (T2D) is a major risk factor for cardiovascular diseases and acute oxidative stress (OS) by high production of reactive oxygen species (ROS) related to the lipotoxicity and glucotoxicity processes. The study was aimed at evaluating the cytokine responses and antioxidant trace elements status using the blood levels of interleukin-1 alpha, interleukin-4, zinc nickel, magnesium, and chromium circulating among antidiabetics drug naïve non-obese male type 2 Diabetic Nigerians. A total of 124 subjects (aged between 20 and 40 year) were randomly studied, among these were 64 known cases of type 2 diabetes mellitus with a poor glycemic control index and 60 apparently healthy individuals with a good glycemic index. Student’s t- test was used to compare independent variables. Cytokine levels were determined by enzyme-linked immunosorbent assay m.. Read More»
  DOI: 10.37421/1948-593X.2022.15.364

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