Institute of Medical Biometry and Informatics, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 105, D-69120 Heidelberg, Germany
Research Article
The Association of Blood Cholinergic Esterases and Other Risk Factors on the Development of Postoperative Delirium
Author(s): Konstanze Plaschke*, Sara-Susan Schulz, Jürgen Hoffmann, Markus A Weigand, Thomas Bruckner, Christoph Schramm and Jürgen Kopitz
Study Objective: Delirium is an important complication after surgical intervention. One of the potential risk
factors for cognitive disorders is deterioration in cholinergic neurotransmission including anticholinergic medications.
We hypothesize that changes in blood cholinesterases (CHE) are associated with postoperative delirium.
Design: Prospective cohort study.
Setting: Postoperative delirium was assessed at least once daily in all included patients (n=103) preoperatively
and on the first and third postoperative day during their stay on the intensive care unit (ICU) or in hospital.
Patients: undergoing a surgery on the head were included.
Interventions and Measurements: Postoperative delirium was assessed using the Intensive Care Delirium
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Journal of Clinical Anesthesiology: Open Access received 7 citations as per Google Scholar report
