Journal of Brain Research

Department of Neuroscience and Philosophy, Agnes Scott College, Decatur, GA, USA

Publications

• Research Article   
  Heterozygote Shank3b Mice Exhibit Sex-Dependent Changes In Proteins Required For Excitatory/Inhibitory Balance
  Author(s): Sophie Gregoretti, Anjali Kunnatha, Lil Gehner, Mykle Williams, Casey Rice, Beck Littlehale, Grace Phillips, Kylie Roach, Rebecca Harshman, Lyric Freeman, Lila McMaster, Laila James, Nadia Small, Erika Vargo, Stacey B.B. Dutton and Jennifer L. Larimore*
  
  Altered expression of SHANK3 proteins has been implicated in multiple neurodevelopmental disorders, including Phelan-McDermid syndrome (PMS), schizophrenia (SZ), and autism spectrum disorders (ASDs). SHANK3B is a postsynaptic density protein that physically links ionotropic NMDA receptors to metabotropic mGlu5 receptors through interactions with scaffolding proteins, a connection essential for long-term potentiation. Previous studies have demonstrated that endosomal trafficking within dendritic spines regulates receptor insertion and recycling, processes fundamental to maintaining excitatory/inhibitory (E/I) balance. Here, we investigated endosomal protein expression and E/I regulatory proteins in a SHANK3B mouse model to better understand sex-dependent contributions to neurodevelopment. Using immunoblotting and immunohistochemistry, we identified sex-specific alterations in hippocamp.. Read More»
  DOI: 10.37421/2684-4583.2025.8.303

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