Journal of Brain Research

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY-10029, USA

Publications

• Research Article   
  A Neural Biomarker for Hallucinations: Medial Prefrontal Aberrations in Neural Connectivity Predict Self-Agency Deficits and Hallucination Severity in Schizophrenia
  Author(s): Shalaila S. Haas, Leighton B.N. Hinkley, Melissa Fisher, Sophia Vinogradov, Srikantan Nagarajan and Karuna Subramaniam*
  
  Prior studies have shown that the medial prefrontal cortex (mPFC) represents one neural substrate that mediates judgments of self-agency (i.e., the awareness that ‘I am the originator of my actions’). Patients with schizophrenia (SZ) manifest cardinal self-agency deficits that contribute to debilitating psychotic symptoms (e.g. hallucinations) and distort reality monitoring. This is the first study in which we examine across 2 SZ samples, the mPFC site that underlies self-agency deficits during an explicit reality-monitoring task (i.e., while subjects distinguish self-generated information from externally-derived information) in one SZ sample, and link Intrinsic functional connectivity (iFC) during rest within this a priori task-evoked self-agency seed with hallucination symptoms in a different SZ sample. In particular, we examined the iFC between the mPFC site th.. Read More»
  DOI: 10.37421/2684-4583.2021.4.127

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