Journal of Oncology Translational Research

Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA

Publications

• Research Article   
  Cardiac Substructure Analysis of Radiation-associated Cardiac Disease in Thoracic Malignancy Patients
  Author(s): Eric Heller*, Kranti A. Mapuskar, Kelli Hawkes, Heba Ismael, Kristin Plichta, Kellie L. Bodeker, Sarah L. Mott, Barry London, Douglas R. Spitz, Bryan G. Allen, Elizabeth A. Chrischilles and Isabella M. Grumbach
  
  Radiation-associated cardiac disease frequently affects cancer patients when radiation fields overlap the heart, but relationships between cardiac substructure dose and specific cardiac events remain poorly understood. This study examined associations between radiation dose to cardiac substructures and adverse cardiac events in thoracic malignancy patients. We retrospectively analyzed 94 patients with lung, esophageal and breast cancers who received radiation therapy. Radiation-induced adverse cardiac events included pericardial disease, atrial fibrillation/flutter, heart failure and valve disease. We evaluated associations between cardiac substructure radiation doses and adverse event types. Results showed that increasing radiation doses to the pericardium, left atrium and whole heart were associated with higher odds of pericardial disease. Median onset times varied: 7 months for per.. Read More»
  DOI: 10.37421/2476-2261.2025.11.331

  Abstract HTML PDF