Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Research Article
The Association between Serum Indoxyl Sulfate, P-Cresyl Sulfate and Cardiovascular Risk Factors in Peritoneal Dialysis Patients
Author(s): Aschalew Fikru Hiruy, Qianqian Xiong, Xiaolei Guo, Qiman Jin, Jing Zhao, Xuechun Lin, Shuiqing He, Chenjiang Ying, Xuezhi Zuo* and Li Li
Background: Indoxyl Sulfate (IS) and p-Cresol Sulfate (pCS) are two important gut-derived uremic toxins accumulated in patients with Chronic Kidney Disease (CKD). They have been reported contributing greatly to Cardiovascular Disease (CVD) both in epidemiological studies and animal models. The present study was conducted to explore whether IS and pCS contribute to CVD by accelerating cardiovascular risk factors in Peritoneal Dialysis (PD) patients.
Methods: A cross-sectional study was conducted on 119 PD patients. Serum IS and pCS were measured by Ultra-High-Performance LC–tandem MS (UPLCMS/ MS), and metabolic parameters involved in cardiovascular risk were measured by auto-biochemistry analyzer machine. Univariate and multivariate linear regression models were performed to determine the association between t.. Read More»
DOI:
10.37421/2161-0959.2021.11.357
Journal of Nephrology & Therapeutics received 784 citations as per Google Scholar report
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