Journal of Clinical Research

Department of Medicine, Jose Maria Morales Meseguer Hospital, Murcia, Spain

Publications

• Research Article   
  Evaluation of the Implementation of a Voriconazole Pharmacokinetic Monitoring Program in Hematological Patients
  Author(s): Paula Torrano Belmonte*
  
  Background: Invasive Fungal Infections (IFI) is a significant cause of morbidity and mortality in patients with hematological malignancies. Voriconazole is widely used for the prophylaxis and treatment of IFIs. However, its efficacy and safety are influenced by factors such as nonlinear pharmacokinetics, genetic polymorphisms, hepatic metabolism, and drug interactions. Pharmacokinetic (PM) monitoring is an essential tool to optimize voriconazole therapy. Objectives: This study aimed to evaluate the impact of the implementation of a voriconazole MF program on drug safety and dosing optimization in hematological patients. Methods: A prospective study was conducted in hospitalized patients with hematological malignancies who received voriconazole between January and December 2023. Inclusion criteria included adults un.. Read More»
  DOI: 10.37421/2795-6172.2025.9.279

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