Department of Molecular Biology, Institute for Biological Research “Siniša Stanković”, National Institute of Republic of Serbia, University of Belgrade, 11060 Belgrade, Serbia
Mini Review
Collaboration of Ferroptosis in Insulin Dependent Diabetes Persuade Adrenal Pathology
Author(s): Nevena Saksida*
Cell death plays an important part in diabetes- convinced liver dysfunction. Ferroptosis is a recently defined regulated cell death caused by iron-dependent lipid peroxidation.
Our former studies have shown that high glucose and streptozotocin( STZ) beget β- cell death through ferroptosis and that ferrostatin- 1 (Fer- 1), an asset of ferroptosis,
improves β- cell viability, island morphology, and function. This study was aimed to examine in vivo the involvement of ferroptosis in diabetes- related pathological changes
in the liver. For this purpose, manly C57BL/6 mice, in which diabetes was convinced with STZ (40 mg/kg/5 successive days), were treated with Fer- 1 (1 mg/kg, from day
1 – 21 day). It was set up that in diabetic mice Fer- 1 bettered serum situations of ALT and triglycerides and dropped liver fibrosis, hepatocytes size, and binucleation. This.. Read More»
DOI:
10.37421/2952-8119.2022.6.120
Journal of Microbial Pathogenesis received 17 citations as per Google Scholar report
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