Journal of Cytology & Histology

Department of Anesthesia, Zagazig University, Zagazig, Egypt

Publications

• Research Article   
  Effects of Single Dose of Intraperitoneal Ketamine on the Liver of Adult Male Albino Rats: Histological and Immunohistochemical Study
  Author(s): Rania AM Wahdan*, Mohamed S. Ali, Moustafa Mohamed Ibrahim Moustafa and Maha Zayed Mohammed Hassan
  
  Background: Ketamine has sedative, dissociative anesthetic and analgesic properties. Ketamine and its metabolites induced hepatic damage with chronic use for treatment of chronic pain. This study examined the effects of single intraperitoneal ketamine doseon adult male albino rats’ liver by applying histological and immunohistochemical methods. Methods: After institutional animal research ethical committee approval, thirty healthy adult male albino rats were equally divided into three groups. Group I received Intraperitoneal (IP) saline in a similar volume to IP ketamine given in group II and III. Group II and Group III had 120 and 160 mg. Kg-1 body weight ketamine single intraperitoneal dose respectively. After 3 days’ rats were killed by decapitation and parts of their livers were processed and stai.. Read More»
  DOI: 10.37421/2157-7099.2024.15.753

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