Journal of Cytology & Histology

The International Center for Training and Advanced Researches (ICTAR), Egypt

Publications

• Research   
  Histopathological, Biochemical and Genetic Profile Post Application of Free Silver Nanoparticles and H₂O₂ Combined Form in Vitro Study
  Author(s): Adel-El-bialy, Ahmed M. Mansour, Tamer M. M. Abuamara, Mohamed E. Amer, Rania I Shbel, Emadeldin R Matar, Mohamed Abulghait and Aly Fahmy Mohamed*
  
  Current studyaimed to evaluate the antiviral activities of free silver nanoparticles (AgNPs) and hydrogen peroxide combined silver nanoparticles(AgNP-H2O2) compared to standard IFN-α2a against Herpes simplex virus type-1 (HSV-1), Vesicular stomatitis virus (VSV) and Middle East respiratory syndrome-coronavirus (MERS-CoV). The related biochemical and pathological changes as well asthe expression levels of antiviral biomarkers, namely Mx-A and 2'-5'-oligoadenylate synthetase (2'-5'-OAS)were investigated. Cytotoxicity of AgNPs and AgNP-H2O2 was monitored against Vero cellsusing MTT assay. Data revealed that the toxicity was concentration dependent and AgNP-H2O2was significantly (P<0.05)toxicthan AgNPs recording an IC50value of 0.864 and7μM/ml, respectively. Oxidative stress markers sh.. Read More»
  DOI: 10.37421/2157-7099.2021.12.564

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