Journal of AIDS & Clinical Research

ISSN: 2155-6113

Open Access

Jean-Luc Kortenaar

St. Michael’s Hospital, Toronto, Canada

  • Research Article   

    Author(s): Jean-Luc Kortenaar, Angela M Cheung, Shabbir Mewa, Esther Waugh, Laurence Rubin and Darrell HS Tan*

    Objective: Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as HIV pre-exposure prophylaxis (PrEP) decreases bone mineral density (BMD). We explored the impact of vitamin D supplementation, dietary calcium intake, and bone loading exercise on BMD during the first 12 months of daily TDF/FTC PrEP. Methods: All participants from the PREPARATORY-5 pilot demonstration project of gay and bisexual men were eligible for inclusion if they had dual-energy X-ray absorptiometry scans at both baseline and 12 months (n=39). Selfreported vitamin D supplementation was collected prospectively, whereas data on diet and exercise was obtained retrospectively after the trial period, using validated questionnaires. We compared median percent changes in BMD and trabecular bone score (TBS) between those with and without vitamin D supplementatio.. Read More»

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