Journal of Nephrology & Therapeutics

Department of Nephrology, Charles University, Prague, Czech Republic

Publications

• Research Article   
  Real−World Data of Protein−Restricted Diets Supplemented with Ketoanalogues in Predialysis Patients− Results of a Prospective Multicentric Observation Study
  Author(s): Jan Vachek, Ileana Peride, Elena Emanuela Rusu, Jiri Vlasak, Tamás Szabo, Aniko Németh, Romana Rysava, Szilvia Kazup, Jan Svojanovsky, Molnár Marta, Erzsébet Rozsnyai, Ligia Petrica, Liliana Tuta, Miklós Mihalcsó, Erzsébet Ladányi and Gábor Zakar*
  
  Background: According to randomized controlled studies, protein-restricted diets supplemented with ketoanalogues effectively prolong the time until dialysis while maintaining nutritional status in patients with chronic kidney disease. The aim of the present study was to investigate whether such effects are also observed in real-world practice. Methods: Multicentre, prospective, observational study over 12 months in 164 predialytic patients on a protein-restricted diet supplemented with ketoanalogues, prescribed according to recent standard of care. Main outcome variables were patients’ compliance, yearly decline in estimated glomerular filtration rate (eGFR), initiation of renal replacement therapy or 50% reduction in initial eGFR (composite endpoint), and time to dialysis start. Results: At basel.. Read More»
  DOI: 10.37421/2161-0959.2022.12.425

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