Journal of Hypertension: Open Access

ISSN: 2167-1095

Open Access

Huaqing Zhao

Department of Clinical Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, USA

  • Research   
    The Association of Serum Aldosterone with Sex, Age, and Sodium Status
    Author(s): Ajay D Rao*, Huaqing Zhao, Ramachandran S Vasan and E Victor Adlin

    Context: In a prior study we observed that adjustment of serum aldosterone for age, sex and sodium status led to confirmation of our hypothesis of bimodality of serum aldosterone in low-renin hypertension; the hypothesis was not statistically supported without this adjustment. Here we aim to further characterize the effect of this statistical adjustment on the normality of the distribution of serum aldosterone. Methods: We analyzed data from 1486 normotensive men and women, aged 29 to 85, in the sixth examination cycle of the Framingham Offspring Study. We used independent two sample t-tests, regression of natural-log-transformed values of aldosterone on age, sex, and urinary sodium: creatinine ratio, the dip test for unimodality, dotplots, and Q-Q plots to study the normality of the distribution of aldosterone concentrations with and without.. Read More»

    Abstract PDF


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