Journal of Hypertension: Open Access

Department of Pharmacy, Apollo College of Pharmacy, Anjora, Durg, C.G, India

Publications

• Research Article   
  New Organic Nitrite Therapy for Acute Experimental Pulmonary Embolism Pulmonary Hypertension
  Author(s): Hari Prasad Sonwani* and Aakanksha Sinha
  
  Because of the elevated pulmonary vascular resistance and arterial hypoxemia caused by acute pulmonary embolism, right heart failure may result. It is imperative that pulmonary hypertension patients receive effective vasodilator therapy. Thus, using a rabbit model of acute pulmonary embolism, we examined the effects of a recently created, potent pulmonary vasodilator called organic mononitrates of 1,2-propanediol (PDNO). Blood gases, plasma nitrite content, exhaled Nitric Oxide (NO), and systemic and pulmonary hemodynamics were measured in anesthetized and ventilated rabbits. PDNO and inorganic nitrite were infused intravenously and into the left ventricle of naive animals, as well as in animals with pulmonary hypertension caused by a thromboxane A2 analogue, in doseresponse tests. Second, an acute pulmonary embolism was created, and after 20 minutes, either PDNO or a placebo was inje.. Read More»
  DOI: 10.37421/2167-1095.2025.14.498

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