Journal of Surgery

Department of Pharmacy, Apollo College of Pharmacy, Anjora Durg C G, 568H+49M, Chhattisgarh, India

Publications

• Research Article   
  NVP-231, a Ceramide Kinase Inhibitor, Causes M Phase Arrest and Consequent Cell Death to Stop the Growth of Breast and Lung Cancer Cells
  Author(s): Hari Prasad Sonwani*
  
  Context and objective: The production of ceramide-1-phosphate, which is catalysed by ceramide kinase (CerK), may influence a number of cellular processes, including inflammation and cell division. Here, we looked at how the newly created CerK inhibitor NVP-231 affected the viability and proliferation of cancer cells, as well as the function of cell cycle regulators linked to these reactions. Experimental methodology: Gradually increasing concentrations of NVP-231 were applied to the lung cancer cell line NCI-H358 and the breast cancer cell line MCF-7 in order to measure DNA synthesis, colony formation, and cell death. The cell cycle distribution of the cells was analyzed using flow cytometry, and alterations in the expression and activation of cell cycle regulators were found using Western blot analysis. Importa.. Read More»
  DOI: 10.37421/1584-9341.2024.20.126

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