Medicinal Chemistry

Department of Pharmaceutical Sciences, South Ural State University, 454008 Chelyabinsk, Russia

Publications

• Mini Review   
  The Hybrid Drug Concept and Recent Advances in Anticancer Hybrids
  Author(s): Habibullah Khalilullah*
  
  Cancer is a complex disease, and treating it is difficult due to the variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a recent drug discovery strategy that involves combining two drug pharmacophores into a single molecule. The hybrid molecule acts on multiple targets simultaneously through distinct modes of action, resulting in greater efficacy and less susceptibility to resistance. As a result, there is enormous potential for using hybrid compounds to address the current challenges in cancer medicine. Recent research has used this technique to discover some intriguing molecules with significant anticancer properties. We present data on a number of promising hybrid anti-proliferative/ anti-tumor agents developed over the previous ten years in this study. Quinazoline, indole, carbazole, pyrimidine, quinoline, quinone, imidazole, selenium, plati.. Read More»
  DOI: 10.37421/2161-0444.2023.13.658

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