Journal of Molecular Biomarkers & Diagnosis

Division of Clinical Pathology, Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

Publications

• Research   
  COVID-19 Spreading Across World Correlates with 677T Allele of the Methylenetetrahydrofolate Reductase (MTHFR) Gene Prevalence
  Author(s): Giovanni Ponti*, Lorenza Pastorino, Gabriella Oliva, Tomris Ozben, Marco Manfredini, Shaniko Kaleci, Nicoletta Lelli, Raffaele Iannella and Aldo Tomasi
  
  Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR 677T allele and COVID-19 incidence and mortality worldwide. There is a clear trend towards the worldwide prevalence of MTHFR 677T allele and COVID-19 incidence and mortality. The prevalence of MTHFR 677T allele in the Latino population and the incidence and mortality for COVID-19 was higher for this ethnic group than that reported for most other populations globally. Statistical analysis showed a relatively strong correlation between 677T allele and death from coronavirus. Genetic polymorphism of MTHFR C677T may modulate the incidence and severity of COVID-19 pandemic infection. .. Read More»
  DOI: 10.37421/2155-9929.2021.12.447

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