Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

Floyd D. Wilson

Mississippi Veterinary Research and Diagnostic Laboratory, Mississippi State University, Pearl, MS 39208, USA

  • Research Article   
    Evaluation of a Morphometric Density Approach for Quantitation of Pneumonia Severity using a Murine Influenza Model
    Author(s): Floyd D. Wilson*, Lanny W. Pace and Frederic J. Hoerr

    Routine 5 μm H&E-stained lung sections were utilized to investigate the capability of histomorphometry for determining pneumonia severity using a murine influenza model. Lung density was measured using the NIH ImageJ software program and the results for binary digital images were compared to corresponding results for semiquantitative pneumonia severity scoring. Lung samples from mice exposed (inoculated controls or IC) or not exposed (non-inoculated controls or NC) to influenza virus were evaluated at 3-, 5-, 7-, 10- and 15-days following exposure. On day 15 the mean density and standard deviation for NC at 25-x were 106 ± 23.6 and for IC 154.9 ± 36.3, and the difference was significant (p ≥ 0.05). Using 400-x measurements NC values were 68.1 ± 8.5 and IC 96.8 ± 16.1 and significant. Significant differences were present at eith.. Read More»
    DOI: 10.37421/2157-7099.2023.14.671

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