Department of Biosciences and Biomedical Sciences, Cardiff University, Cardiff, Wales, UK
Why primary tumours/malignancies of the nerve cells are so rare?
Author(s): Eliza Roche*
Introduction: Primary tumours associated with nerve cells are exceptionally rare whereupon the majority of these tumours present as benign. Neurons develop oncogenic mutations less than their supporting neuroglias which are transformed into glioma tumours. Methods and materials: Using a multi-faceted approach, search strategies were generated using specific keywords and performed on selected scientific databases. Literature searches were performed and a shortlist of seven publications was generated following a strict criteria based selection process. Results: Reduced number of proliferating cells: Early cell cycle exit results in the inability for nerve cells to regenerate as well as preventing malignancies from developing as no DNA is required to replicate. Additionally, post-mitotic Neurons have the abili.. Read More»
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