Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

El-Bisari S

Dr, Health Plus Genomics Laboratory, Abu Dhabi, United Arab Emirates

  • Research Article   
    Chromosomal Mosaicism in Cleavage Stage Embryos vs. Blastocyst Stage Embryos
    Author(s): El-Bisari S*, Alyounis D, Sayed W and Uppal S

    Introduction: Chromosomal mosaicism is characterized by the presence of more than one chromosomally different cell line in an individual. Preimplantation chromosomal mosaicism is characterized by the presence of a mixture of chromosomally different cell lines in an embryo. Studies show that mosaicism for whole chromosomes (aneuploidies) in one or more cells (blastomeres) occurred in more than 75% of cleavage stage embryos, whilst 3%-24% of blastocyst stage embryos are chromosomally mosaic. Aim: The purpose of this study was to standardize and validate a Next Generation Sequencing (NGS) method for comprehensive chromosome testing for aneuploidies and to study the level of mosaicism in cleavages stage vs. blastocyst stage embryos. Methods: The validation involved a retrospective blind assessment of whole genome amplifica.. Read More»
    DOI: 10.37421/jmgm.2020.14.462

    Abstract PDF

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