Malaria Control & Elimination

ISSN: 2470-6965

Open Access

D Bharali

Département of Pharmaceutical Chemistry, NETES Institute of Pharmaceutical Science, Kamrup-781125, India

  • Research Article   
    Tetrazole Moiety as a Pharmacophore in Medicinal Chemistry: A Review
    Author(s): B Deka*

    In present day scenario, tetrazole has gained increasing popularity due to its broad-spectrum of biological properties such as antitubercular, anticancer, antimalarial, antidiabetic, antifungal, anti-inflammatory activities etc. Tetrazole, beinga bioisostere of the carboxylic acid group can replace the carboxyl group in drugswhich can be utilized to increase the lipophilicity, bioavailability and to reduce theside effects of drugs. Many tetrazole containing compounds have already been used for the treatment of various diseases primarily due to their better pharmacokineticprofile and metabolic stability. Therefore, this heterocyclic tetrazole moiety having admirable biological, pharmaceutical and clinical applications can be considered as an important pharmacophore in the development of new drugs.The presentsurveyreviews the various approaches available for the synthesis of tetrazole d.. Read More»
    DOI: 10.37421/2470-6965.2021.10.167

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