Journal of Hypertension: Open Access

Department of Human Physiology, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa

Publications

• Research Article   
  The Effects of Chronic Cannabinoid Administration on the Haematological Parameters, Oxidative Stress, BNP, and the Gene Expression of TNF?A in a Rat Model of Pulmonary Arterial Hypertension
  Author(s): Chayil Gunpath*
  
  Pulmonary arterial hypertension is a rare but a rapidly increasing prevalent pulmonary disease that is characterised by vasoconstriction and inflammation of the pulmonary arteries leading to elevated pressure in the system eventually causing right heart failure and death. Cannabidiol (CBD), which is the major non-psychoactive component of cannabis, has substantial anti-inflammatory, immunomodulatory, and analgesic effects. This study investigated the therapeutic potential of cannabidiol alone, and adjunctive therapy with selexipag, used in the treatment of PAH, by investigating its effects on the expression of the inflammatory and hypoxic biomarker, TNF-α, as well as the effect on BNP levels and oxidative stress in the blood and heart in a Monocrotaline (MCT)-induced PAH rat model. Forty male Sprague-Dawley rats were divided into 5 groups of 8 animals consisting of: Control, MCT.. Read More»
  DOI: 10.37421/2167-1095.2025.14.499

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