Journal of Brain Research

Department of Pathology, Jinnah Medical College, Khyber Medical University, Peshawar, Pakistan

Publications

• Research Article   
  Immunohistochemical Expression Levels of CD133 Cancer Stem Cell Marker in Glioma Patients
  Author(s): Sabeen Nasir*, Asif Ali and Shabnam Wazir
  
  Background: The most prevalent kind of brain tumours are gliomas, and because of their high recurrence rates, managing them is still difficult. The development, progression, and treatment resistance of gliomas have all been linked to Cancer Stem Cells (CSCs). A well-known CSC marker, CD133, is essential to the biology of gliomas and may be a prognostic predictor. Objective: To assess the immunohistochemistry expression levels of CD133 in patients with gliomas and link them with the histological type and tumour grade. Methods: We used Tissue Microarrays (TMAs) to assess 128 glioma tissue samples. The Immunoreactive Score (IRS) was employed to measure staining intensity, and immunohistochemical staining was used to identify CD133 expression. The Chi-square test was used for statistical comparisons, and SPSS software was used for data analysis... Read More»
  

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