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Pharmaceutical Regulatory Affairs: Open Access

ISSN: 2167-7689

Open Access

André Limonta Carvalho

New Max Industry, Brazil

Publications
  • Review   
    Risk Assessment of Tocotrienols from Annatto (Bixa orellana L.): Regulatory Contributions
    Author(s): Talita da Silva Ferreira*, Paulo Roberto Nogueira Carvalho and André Limonta Carvalho

    Tocotrienols are found naturally in several plant sources, mainly in grains and oils, such as wheat germ, soybean oil, barley, oats, and olive oil. However, these sources have much lower concentrations of tocotrienols. Higher concentrations of tocotrienols are found in Annatto (Bixa orellana L.) seeds. The monograph Dietary Supplement Compendium (DSC) from the United States Pharmacopeia for Annatto Seed Oil Tocotrienols defines that tocotrienols fraction must contain at least 70% of total tocotrienols, calculated on an anhydrous basis of the total tocotrienol content, it must contain between 84% and 92% of δ-Tocotrienol and between 8% and 16% of γ-tocotrienol. The risk assessment with NaturalMax Annatto Tocotrienol™ Oil 70%, extracted from annatto seeds, provided 100% tocotrienols (gamma and delta-tocotrienol) less than 1% α-to.. Read More»
    DOI: 10.37421/2167-7689.2021.10.262

    Abstract HTML PDF

Google Scholar citation report
Citations: 533

Pharmaceutical Regulatory Affairs: Open Access received 533 citations as per Google Scholar report

Pharmaceutical Regulatory Affairs: Open Access peer review process verified at publons

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