China						                            
                            
						
 Research Article
												Diastolic Pulmonary Arterial Pressure as a Prognostic Indicator for Closure of Atrial Septal Defect with Severe Pulmonary Arterial Hypertension 						
Author(s): Yan Chaowu, Pan Xiangbin, Xu Zhongying, Zhang Gejun, Zheng Hong, Jin Jinglin, Li Shiguo, Lv Jianhua, Hu Haibo, Song Huijun, Liu Qiong, Wan Junyi, Xu Liang, Zhu Zhenhui, Pang Kunjing and Wang YangYan Chaowu, Pan Xiangbin, Xu Zhongying, Zhang Gejun, Zheng Hong, Jin Jinglin, Li Shiguo, Lv Jianhua, Hu Haibo, Song Huijun, Liu Qiong, Wan Junyi, Xu Liang, Zhu Zhenhui, Pang Kunjing and Wang Yang             
						
												
				 Background: In patients with atrial septal defect (ASD) and severe pulmonary arterial hypertension (PAH), diastolic pulmonary arterial pressure (DPAP) correlates closely with pulmonary vascular resistance (PVR) and can reflect the severity of pulmonary vascular disease. However, it is unclear whether DPAP has potential to become a prognostic indicator for closure of ASD with severe PAH. Objectives: This study was performed to investigate the prognostic implication of DPAP in patients with ASD and severe PAH. Methods: Among 232 patients with ASD and severe PAH (systolic pulmonary arterial pressure (SPAP)≥70 mm Hg measured with right heart catheterization), 85 patients (21M/64F) undergoing closure of ASD were followed up. Doppler-calculated SPAP was recorded to identify the normalized post-operative PAP (SPAP<40 mm Hg). According to the cut-off value of DPAP from a ROC curve, two .. Read More»
				  
												DOI:
												 10.4172/2167-1095.1000231 
																	  
Journal of Hypertension: Open Access received 614 citations as per Google Scholar report