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Human Genetics & Embryology

ISSN: 2161-0436

Open Access

Zev Zlatopolsky


Tanzania

Publications
  • Research Article
    Chromosomal Abnormalities in Reimplantation Development
    Author(s): Anver Kuliev, Zev Zlatopolsky and Svetlana RechitskyAnver Kuliev, Zev Zlatopolsky and Svetlana Rechitsky

    Direct testing of the outcome of human female meiosis demonstrated that up over a half of oocytes from IVF patients of advanced reproductive age are aneuploid, originating comparably from meiosis I and meiosis II errors, with potential probability of aneuploidy rescue in an almost half of oocytes with sequential first and second meiotic errors. One fifth of abnormalities originating from meiosis I and II are of complex nature, with nonrandom distribution of chrmomatid/chromosome (10:1 ratio), and missing/extra chromotid (chromosome) errors (2:1 ratio). The data also demonstrate the relationship between embryo viability and meiotic origin of chromosomal errors, affecting their clinical impact on preimplantation and post-implantation development .. Read More»
    DOI: 10.4172/2161-0436.1000134

    Abstract PDF

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Citations: 309

Human Genetics & Embryology received 309 citations as per Google Scholar report

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