Journal of Cytology & Histology

Yuzuru Kotake

Publications

• Research Article
  Use of Localization and Activity of Thymidine Phosphorylase in Human Gynecological Tumors for Predicting Sensitivity to Pyrimidine Antimetabolite Therapy: An Observational Study
  Author(s): Yuzuru Kotake, Toru Sasaki, Hiroshi Sasaki, Minoru Akiyama, Kazunori Ochiai, Shinji Sato, Akira Yajima, Kazuo Hasegawa, Michiaki Yakushiji, Shinichi Tsuchiya and Kiichiro NodaYuzuru Kotake, Toru Sasaki, Hiroshi Sasaki, Minoru Akiyama, Kazunori Ochiai, Shinji Sato, Akira Yajima, Kazuo Hasegawa, Michiaki Yakushiji, Shinichi Tsuchiya and Kiichiro Noda
  
  Background: Thymidine phosphorylase (dThdPase) is the rate-limiting enzyme in the conversion of 5 ′ -deoxy- 5-fluorouridine (5 ′ -dFUrd), an intermediate metabolite of capecitabine (Xeloda ® ), to 5-fluorouracil (5-FU). We investigated the correlation between dThdPase activity and immunohistochemical staining in gynecological carcinoma and adjacent normal tissues. We hypothesize that the differential dThdPase activity between tumors and adjacent tissue is predictive of response to treatment with pyrimidine antimetabolites. Methods: In 45 samples of carcinoma tissue and 35 of adjacent normal tissue from 45 patients, we measured dThdPase activity as well as immunoreactivity using an anti-dThdPase monoclonal antibody and macrophage and histiocyte-specific antibodies. Results: d.. Read More»
  DOI: 10.4172/2157-7099.1000121

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