Journal of Hypertension: Open Access

Yunfu Lv

Publications

• Research Article
  Expression and Importance of Interleukin-17 and Transforming Growth Factor-�Ž�² in the Spleens of Hypersplenic Rats
  Author(s): Yunfu Lv, Qingqing Li, Jie Deng and Shuyong YuYunfu Lv, Qingqing Li, Jie Deng and Shuyong Yu
  
  Objective: We analyzed the expression of interleukin-(IL)-17 and transforming growth factor (TGF)-β in the spleens of rats suffering from liver cirrhosis and hypersplenism, and investigated the cause of peripheral cytopenias. Methods: Fifty-five male Sprague–Dawley rats were divided randomly into two groups. The control group (n=15) was gavaged with physiologic (0.9%) saline. The experimental group (n=40) was gavaged with 40% CCL4/peanut oil solution at 0.3 mL/100 g twice a week for 8 weeks, and a 15% alcohol solution was given as drinking water, to establish a model of liver cirrhosis and hypersplenism. After confirmation of liver cirrhosis and hypersplenism, spleen tissue was collected to determine expression of IL-17 and TGF-β by Immuno Histo Chemical (IHC), western blotting, and real-time fluorescence-based quantitative poly.. Read More»
  DOI: 10.4172/2167-1095.1000246

  Abstract PDF