Molecular and Genetic Medicine

Yun Wang

Publications

• Research Article
  Genetic Study of 12 SNPs involved in 11 Folate Metabolism Genes and Neural Tube Defects in Suzhou Children
  Author(s): Qin Zhu, Li Li, Ting Wang, Wei Jiang, Jie Ding, Minjuan Liu, Yun Wang and Haibo LiQin Zhu, Li Li, Ting Wang, Wei Jiang, Jie Ding, Minjuan Liu, Yun Wang and Haibo Li
  
  Objective: Neural tube defect (NTD) incidence could be effectively reduced by folic acid supplementation before and during pregnancy. We studied single nucleotide polymorphisms (SNPs) involved in folate metabolism to explore genetic susceptibility to NTD. We studied the association between 12 SNPs involved in 11 folate metabolism genes and NTDs. Methods: We enrolled 76 children with NTD and 188 control children. We genotyped 12 folate metabolism SNPs including CBS-C699T, DHFR-c594+59del19, GSTO1-C428T, MTHFD-G1958A, MTHFR-C677T, MTHFR-A1298C, MTR-A2756G, MTRR-A66G, NFE2L2-ins1+C11108T, RFC1-G80A, TCN2-C776T, and TYMS-1494del6 using SNaPShot genotyping technology and confirmed by Sanger sequencing. Results: One SNP, TYMS-1494del6, and one compound wide-type genotype of RFC1-G80A, MTHFR-A1298C and TCN2-C776T might de.. Read More»
  

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