Journal of Cytology & Histology

Youssef Haikel

Publications

• Review Article
  Cancer Associated Cachexia; Etiopathogenesis, Molecular Mechanisms and Therapeutic Strategies
  Author(s): Mohamed Hassan, Abdelouahid El-khattouiti, Youssef Haikel and Mossaad MegahedMohamed Hassan, Abdelouahid El-khattouiti, Youssef Haikel and Mossaad Megahed
  
  Cachexia is a multifunctional syndrome that is characterized by anorexia and extensive loss of adipose tissue and skeletal muscle, is common in many chronic and advanced diseases. Most of cancer patients show variable patterns of body loss that is known as cancer associated cachexia (CAC). Although CAC share common characteristics, the severity of this disease is variable, and seems to be tumor type, site and stage-dependent. The etiology of cachexia is attributed to abnormal metabolism that is thought to be mediated by tumor- and host-derived cytokines and factors. Although the role of cytokines in the etiology of CAC has been reported, the molecular mechanisms regulating its occurrence in cancer patients are not described in details. This review focuses on the etiopathogenesis of CAC and the underlying mechanisms... Read More»
  DOI: 10.4172/2157-7099.1000271

  Abstract PDF