Case Center for Imaging Research,
Case Western Reserve University, Cleveland, OH 44106
Tanzania
Research Article
In vivo Quantification of Abasic Sites for Efficacious Evaluation of DNA Targeted Chemotherapies
Author(s): Wenxia Zhu, Chunying Wu, Yuguo Li, Eduardo Somoza, Lili Liu, Stanton Gerson and Yanming WangWenxia Zhu, Chunying Wu, Yuguo Li, Eduardo Somoza, Lili Liu, Stanton Gerson and Yanming Wang
DNA damage and repair represent important biological processes that are targets of various chemotherapies against cancer. In many ways, chemotherapeutic agents can induce DNA damage in cancerous as well as normal cells. However, DNA damage induced by chemotherapeutic agents can be intrinsically repaired by normal physiologic responses, which hampers inhibition of tumor growth and cause drug-resistance. Base excision repair (BER) is one such physiologic process that is important in the cellular response to many chemotherapeutic agents, specifically those agents that target DNAs. Once the BER pathway is triggered, damaged DNA bases undergo a series of chemical modifications resulting in the formation of abasic or apurinic/apyrimidinic (AP) site, which serves as key intermediates in the excision of damaged DNA bases and restoration of regular bases. To monitor BER- .. Read More»
DOI:
10.4172/1948-5956.S5-006
Cancer Science & Therapy received 3968 citations as per Google Scholar report