Journal of Clinical & Medical Genomics

Vasiliki E Kalodimou

Publications

• Research Article
  Human Papillomavirus: Flow Cytometry Detection and PCR Analysis, A Comparison Study
  Author(s): Vasiliki E Kalodimou, Marina Kontogiorgi, Abraham Ghiatas and Apostolos PapaloisVasiliki E Kalodimou, Marina Kontogiorgi, Abraham Ghiatas and Apostolos Papalois
  
  Recent reports have shown that during persistent HPV infections of the cervical epithelium the viral genome, of high risk HPV types, often integrate into the host chromosome, which results in an over expression of the viral proteins E6 and E7 of human papillomavirus. These oncoproteins induce immortalization and malignant transformation of cells conferring a certain growth advantage to the infected cells. A total of 100 women undergoing routine cervical cytology samples joined this cohort study. A Thin Prep Pap Test sample was taken following consent for study participation and was tested for HPV. Cytological screening of the samples was done by trained cytologists. After sample collection, 1 ml aliquot was removed and prepared for flow cytometric analysis and the rest of the sample was sent for PCR analysis. In the total of 100 cases, 4 specimens were characterized as unsat.. Read More»
  DOI: 10.4172/2472-128X.1000128

  Abstract PDF