Journal of Lung Diseases & Treatment

Tsukamoto K

Publications

• Research Article
  A Combination Polymorphism of the Glutathione Synthesis Genes can be a Predictive Biomarker for Anti-Tuberculosis Drug-Induced Hepatotoxicity in Japanese Patients with Pulmonary Tuberculosis
  Author(s): Mawatari T, Yoshida E, Higuchi N, Sato K, Inamine T, Kondo S, Fukushima K, Suyama N, Mukae H, Kohno S and Tsukamoto KMawatari T, Yoshida E, Higuchi N, Sato K, Inamine T, Kondo S, Fukushima K, Suyama N, Mukae H, Kohno S and Tsukamoto K
  
  Background: To identify certain genes related to anti-tuberculosis drug-induced hepatotoxicity (ATDH) for Japanese patients with pulmonary tuberculosis (TB), we examined an association study of single nucleotide polymorphisms (SNPs) in candidate genes in glutathione synthesis with susceptibility to ATDH. Method: We studied 100 TB patients treated with anti-TB drugs. The frequencies of alleles and genotypes of 17 tag SNPs in 3 genes between TB patients with and without ATDH were compared by chi-square test or Fisher's exact test in three different inheritance models. A genetic testing was carried out using a single or combination of the associated SNP(s) as a biomarker. Results: Statistical analyses indicated that a C/C genotype of rs553822 in glutamate cysteine ligase, catalytic subunit (GCLC) and an A/T or T/T genot.. Read More»
  DOI: 10.4172/2472-1018.1000105

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