Journal of Hypertension: Open Access

Tomasz Irzyniec

Publications

• Research Article
  Determination of Ghrelin?s Role in the Pathogenesis of Pregnancy Induced Hypertension
  Author(s): Izabela Ulman-Włodarz, Tomasz Irzyniec, Ewa Galbierz- Kwiatkowska and Izabela Maciejewska-PaszekIzabela Ulman-Włodarz, Tomasz Irzyniec, Ewa Galbierz- Kwiatkowska and Izabela Maciejewska-Paszek
  
  Background: Ghrelin is a stomach-produced polypeptide hormone that stimulates hunger and secretion of growth hormone. Abnormalities in ghrelin secretion are well documented in obese patients, but explored little in patients with various forms of hypertension. Notably, ghrelin is indirectly involved in blood pressure regulation in pregnancy induced hypertension. Material and methods: The present study aimed to assess ghrelin concentration in venous blood of 19 nonpregnant (NP), 20 healthy pregnant (HP) and 20 hypertensive pregnant (PIH). It also included assessing blood ghrelin concentration of 21 obese hypertensive pregnant (OPIH) women before and one hour after eating. Ghrelin secretion was estimated 1-3 days before delivery. Results: All experimental groups of pregnant women (HP, PIH, and OPIH) showed significantly reduced ghrelin plasma level as compared with NP (812 ± 83, 716.. Read More»
  DOI: 10.4172/2167-1095.1000201

  Abstract PDF