Pulmonary & Respiratory Medicine

Stephanie D Davis

Publications

• Research Article
  Ventilation Heterogeneity and Airway Hyperreactivity in Children with Well Controlled Asthma
  Author(s): Santiago José Assaf, Charles Curtis Clem, Lauren Bockstahler Jewett, Leah Schornick, Christina Jo Tiller, Jeffrey A Kisling, Stephanie D Davis and Robert S TepperSantiago José Assaf, Charles Curtis Clem, Lauren Bockstahler Jewett, Leah Schornick, Christina Jo Tiller, Jeffrey A Kisling, Stephanie D Davis and Robert S Tepper
  
  Rationale: In asthma, airway inflammation, obstruction and reactivity may lead to ventilation heterogeneity; our understanding of this process is limited in asthmatic children. Objectives and Methods: The study’s objective was to measure ventilation heterogeneity, by the lung clearance index (LCI), in children with well controlled asthma and assess the association of LCI with airway reactivity through methacholine challenge tests. LCI and spirometry were measured in 24 children with asthma and 21 healthy controls between 4 and 10 years of age. Sixteen children with asthma and 11 healthy controls also performed methacholine challenge tests. Results: LCI was higher in children with asthma compared to healthy controls (7.58 vs 6.79, p=0.004); no differences in FEV1 or FEF25-75 were noted between groups. Ages were similar (p=0.54); however, the s.. Read More»
  DOI: 10.4172/2161-105X.1000321

  Abstract PDF