Journal of Metabolic Syndrome

Spagnuolo MI

Publications

• Review Article
  Metabolic Disorders in HIV-infected Children Metabolic Disorders in HIVinfected Children
  Author(s): Spagnuolo MI, Liguoro I and Guarino ASpagnuolo MI, Liguoro I and Guarino A
  
  The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohypertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohypertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some mechanisms have been described, including leptin and adiponectin deficiency, mitochondrial dysfunction and use of antiretroviral drugs. Th.. Read More»
  DOI: 10.4172/2167-0943.1000169

  Abstract PDF