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Journal of Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Shahid Bashir


Saudi Arabia

Publications
  • Research Article
    Indian Hedgehog Protein Levels in Autistic Children: Preliminary Results
    Author(s): Shahid Bashir and Laila AL-AyadhiShahid Bashir and Laila AL-Ayadhi

    The etiology of autism spectrum disorders (ASD) is not well known but recently we reported that the serum levels of sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD. We hypothesized that Indian hedgehog (IHH) protein which belongs to SHH family may play a pathological role in the ASD. We studied recently diagnosed patients in early stages of ASD (n=54) and age-matched, cognitively normal, individuals (n=25), using serum levels of IHH protein. We found statistically significantly higher-levels of serum IHH protein in ASD subjects (p=0.001) compared to control subjects. Our findings are the first to report a role of IHH in ASD children, suggesting a possible pathological role-played by IHH in early-stage in ASD. Such measures might constitute an early biomarker for ASD and ultimately offer a target for novel biomarker-b.. Read More»
    DOI: 10.4172/2155-9929.1000134

    Abstract PDF

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Citations: 2054

Journal of Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report

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