Journal of Nephrology & Therapeutics

Sergio VO

Publications

• Short Communication
  Pre Filter Hemodiafiltration with Heparin-Dose Minimization: A Safe and Effective Technique
  Author(s): Sergio VO, Mónica SC, Evelyn CDR, Raúl I, Enzo VJ and Héctor PGGSergio VO, Mónica SC, Evelyn CDR, Raúl I, Enzo VJ and Héctor PGG
  
  Background: Unfractionated heparin (UFH) administered during hemodialysis (HD) has cumulative adverse effects; hence the importance of using the lowest possible dose and avoid overdosing. Methods: We analyzed 30 patients with chronic hemodiafiltración (HDF) treatment divided in 3 groups: pos filter HDF with heparin standard impregnation dose (27 ± 6.5 IU/kg), HDF pos filter with impregnation low dose (15 ± 4.2 IU/ kg); in both groups, heparin impregnation and maintenance were given, and a third group HDF pre-dilution only with heparin impregnation dose (27 ± 12.8 IU/kg). We measured partial thromboplastin time (aPTT) and serum heparin levels at 30 and 190 min, in the three groups. Results: HDF pre-dilution group received a significantly lower total dose than the other 2 groups; 1750 vs. 2650/3444 UI/Kg (p<0.001), maintaining 30 min aPTT target (55.6 &plu.. Read More»
  DOI: 10.37421/jnt.2019.9.336

  Abstract PDF