Veterinary Science & Technology

RK Peters

Publications

• Research Article
  Free-to-Bound Serum Phenobarbital Levels in Dogs
  Author(s): RM Clemmons, TA Schubert, RK Peters and BL ConradRM Clemmons, TA Schubert, RK Peters and BL Conrad
  
  Monitoring phenobarbital levels in dogs has not traditionally taken free-to-bound serum phenobarbital levels into consideration. This study was designed to evaluate free-to-bound phenobarbital in healthy research dogs during the initiation of therapy with phenobarbital. These findings were compared with the levels obtained during routine therapeutic monitoring of phenobarbital in epileptic dogs. This appears to be the first descriptive study which has looked at free-to-bound phenobarbital in clinical canine patients. During the first week of therapy in healthy canine subjects, the free-to-bound ratio was 0.7 due to the high degree of protein-binding of serum phenobarbital. This was in contrast to the level of protein-binding in epileptic patients receiving phenobarbital chronically, with a free-to-bound ratio of 3.0 ± 2.7. Moreover, during the initiation of the.. Read More»
  DOI: 10.4172/2157-7579.1000143

  Abstract PDF